Dr. A. Heiskanen, Professor J. Emnéus (auth.), Noam Eliaz's Applications of Electrochemistry and Nanotechnology in PDF

By Dr. A. Heiskanen, Professor J. Emnéus (auth.), Noam Eliaz (eds.)

ISBN-10: 1461403464

ISBN-13: 9781461403463

Topics in quantity fifty two include:

· tracking of mobile dynamics with electrochemical detection techniques

· primary stories of lengthy- and short-range electron trade mechanisms among electrodes and proteins

· Microbial gasoline phone scalability and functions in robotics

· Electrochemical coating of scientific implants

· Electrochemical ideas for acquiring biofunctional materials

· guidance and homes of bioactive metals ready through floor modification

From studies of earlier volumes:

“This long-standing sequence maintains its culture of supplying top of the range reports of demonstrated and rising topic parts, including the fewer universal elements of electrochemical science... [and]... merits a spot in electrochemistry libraries and may end up beneficial to electrochemists and similar workers.”

Chemistry and Industry

“Extremely well-referenced and extremely readable.... keeps the general excessive criteria of the series.”

Journal of the yank Chemical Society

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Additional resources for Applications of Electrochemistry and Nanotechnology in Biology and Medicine I

Sample text

This is the consequence of cytosolic inhibition of dehydrogenases. WA cells is significantly higher in the presence of dicoumarol. In the case of EBY44 cells, glucose is predominantly catabolized in the PPP resulting in the formation of NADPH, which does not influence the mitochondrial functions, hence primarily revealing the effect of cytosolic inhibition of dehydrogenases. WA cells, on the other hand, catabolize glucose in both the PPP and GP, the latter of which results in formation of cytosolic NADH.

69 In light of these examples, it is clear that there is a direct connection between the toxicity of many chemicals and CRE, which involves the pools of cellular redox couples and cellular catabolism. The defense mechanisms provided by Cyt P450 and NQO1 have a fundamental difference; Cyt P450 catalyzes one-electron reduction, while NQO1 catalyzes two-electron reduction. , liver, lung, colon, breast73 and pancreatic74 cancer, NQO1 gene expression is up-regulated. 75. 76 Upon autoxidation of these compounds, the resulting oxidative stress selectively causes apoptosis in cancer cells.

If a concentration-dependent response is needed an individual determination in a different aliquot of the cell lysate has to be made. , each determined factor of CRE is independent of the cellular machinery that controls the metabolic fluxes and cellular signaling. These disadvantages in performing assays using cell lysates have led to development towards methods capable of realtime monitoring of cellular dynamics. (ii) Techniques for Live Cells (a) Fluorescence techniques The reduced forms, NADH and NADPH, possess characteristic fluorescence spectra, which can be used for their detection in living cells.

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Applications of Electrochemistry and Nanotechnology in Biology and Medicine I by Dr. A. Heiskanen, Professor J. Emnéus (auth.), Noam Eliaz (eds.)

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